Abstract Introduction: The purpose of this study was to investigate the health status and quality of life of patients receiving maintenance hemodialysis(MHD) in coastal areas of Zhejiang Province and explore the influencing factors of quality of life.Methods: This study selected MHD patients from four hospitals in the coastal area of Zhejiang province as the research objects and collected the sociodemographic characteristics, objective physiological condition, self-feelings of health status and quality of life through questionnaire surveys. One-way analysis of variance and multiple linear regression analysis were used to analyze the factors affecting the quality of life of MHD patients.Results: A total of 140 MHD patients were included in this study. The results showed that the average score of general physical health was 42.89±9.86, general psychological health was 46.71±7.42, kidney disease-related symptoms was 77.95±10.82, kidney disease impact was 64.98±12.03 and kidney disease-related burden was 32.01±19.35. There were significant differences in subscale scores and total scores according to different gender, age, education level, employment status, marital status, self-feelings of physical health, self-feelings of appetite status and self-feelings of sleep quality status groups(P<0.05). The results of multiple linear regression analysis showed that patients with poor self-feelings of physical health status, poor self-feelings of appetite status and poor self-feelings of sleep quality had worse quality of life(P<0.05).Conclusion: Self-feelings of physical health status, self-feelings of appetite status and self-feelings of sleep quality are the main factors affecting the quality of life of MHD patients. Medical staff need to pay more attention to the self-feelings of health status of MHD patients, so as to improve the quality of life of MHD patients.