基因组
霰弹枪测序
生物
基因组
猎枪
计算生物学
微生物群
顺序装配
细菌基因组大小
遗传学
基因
基因表达
转录组
作者
Yunyan Zhou,Min Liu,Jiawen Yang
标识
DOI:10.1016/j.micres.2022.127023
摘要
Reference genomes are essential for analyzing the metabolic and functional potentials of microbiomes. However, microbial genome resources are limited because most of microorganisms are difficult to culture. Genome binning is a culture-independent approach that can recover a vast number of microbial genomes from short-read high throughput shotgun metagenomic sequencing data. In this review, we summarize methods commonly used for reconstructing metagenome-assembled genomes (MAGs) to provide a reference for researchers to choose propriate software programs among the numerous and complicated tools and pipelines that are available for these analyses. In addition, we discuss application prospects, challenges, and opportunities for recovering MAGs from metagenomic sequencing data.
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