钯
荧光
检出限
离子
化学
细胞器
螯合作用
纳米技术
生物物理学
组合化学
材料科学
色谱法
无机化学
生物化学
生物
光学
物理
催化作用
有机化学
作者
Qiuchen Liu,Songtao Cai,Chang Liu,Song He,Liwei Zhao,Xianshun Zeng,Jicheng Gong
出处
期刊:Dalton Transactions
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:51 (8): 3116-3121
被引量:9
摘要
Considering the scarcity of palladium ion probes with subcellular organelle targeting, especially probes with near-infrared (NIR) emission wavelength fluorophores, our group has been working to overcome this problem and looking forward to providing potential practical tools for exploring the toxicity of palladium ions at the subcellular level. In this paper, a novel colorimetric and NIR fluorescent probe, BHCy-Pd, for the specific detection of palladium ions (Pd2+) in lysosomes via an internal charge-transfer (ICT) mechanism was designed and synthesized. As expected, BHCy-Pd exhibited a rapid, selective, and sensitive response for palladium with an ultralow limit of detection at 5.9 nM, accompanied by a distinct color change from purple to blue. Furthermore, BHCy-Pd can be made into a simple test strip for rapid and easy detection of Pd2+ in practical applications. Importantly, BHCy-Pd is capable of specific distribution in lysosomes, and thus can detect Pd2+ in real-time, thereby providing a potential tool for studying the cytotoxicity of Pd2+ ions at the subcellular level.
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