生物
转录组
细胞生物学
胚胎
核糖核酸
效应器
体细胞
信使核糖核酸
卵母细胞
配子发生
功能(生物学)
基因表达
遗传学
胚胎发生
基因
作者
Zhi-Yan Jiang,Heng‐Yu Fan
标识
DOI:10.1093/biolre/ioac014
摘要
Abstract RNA—the primary product of the genome—is subject to various biological events during its lifetime. During mammalian gametogenesis and early embryogenesis, germ cells and preimplantation embryos undergo marked changes in the transcriptome, including mRNA turnover. Various factors, including specialized proteins, RNAs, and organelles, function in an intricate degradation system, and the degradation selectivity is determined by effectors and their target mRNAs. RNA homeostasis regulators and surveillance factors function in the global transcriptome of oocytes and somatic cells. Other factors, including BTG4, PABPN1L, the CCR4-NOT subunits, CNOT6L and CNOT7, and TUTs, are responsible for two maternal mRNA avalanches: M- and Z-decay. In this review, we discuss recent advances in mRNA degradation mechanisms in mammalian oocytes and preimplantation embryos. We focused on the studies in mice, as a model mammalian species, and on RNA turnover effectors and the cis-elements in targeting RNAs.
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