A role for guanidino compounds in the brain.

Guanidino compounds of guanidinoethanesulfonic acid, guanidinoacetic acid, guanidinosuccinic acid, N-acetylarginine, 3guanidinopropionic acid, creatinine, y-guanidinobutyric acid, arginine, guanidine, methylguanidine, homoarginine and aguanidinoglutaric acid are present in the mammalian brain. These guanidino compounds except for arginine and guanidine induce seizures and convulsions in rat, rabbit and cat by intracisternal injection.