嵌合抗原受体
免疫疗法
细胞疗法
热情
免疫学
好奇心
抗原
医学
受体
T细胞
细胞
生物
癌症研究
免疫系统
心理学
神经科学
内科学
遗传学
社会心理学
作者
Saar Gill,Marcela V. Maus,David L. Porter
出处
期刊:Blood Reviews
[Elsevier]
日期:2016-05-01
卷期号:30 (3): 157-167
被引量:192
标识
DOI:10.1016/j.blre.2015.10.003
摘要
Chimeric antigen receptor (CAR) T cell therapy of cancer is generating enormous enthusiasm. Twenty-five years after the concept was first proposed, major advances in molecular biology, virology, and good manufacturing practices (GMP)-grade cell production have transformed antibody-T cell chimeras from a scientific curiosity to a fact of life for academic cellular immunotherapy researchers and, increasingly, for patients. In this review, we explain the preclinical concept, outline how it has been translated to the clinic, and draw lessons from the first years of CAR T cell therapy for the practicing clinician.
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