Assembly of Highly Functionalized Allylic Sulfones via a Stereoselective Pd‐Catalyzed Sequential C−C/C−S Cleavage and C−S Formation Process

Abstract A Pd‐catalyzed sequential C−C/C−S cleavage and C−S formation approach for highly functionalized allylic sulfones synthesis of vinylcyclopropanes with p ‐tosylmethyl isocyanide has been developed under mild conditions. Importantly, the reaction of modular VCPs and TosMIC would give access to ( E )‐allylic sulfones in a stereoselective and regioselective fashion onto the in situ formed Pd intermediate. The current protocol featured broad substrate scope, operational convenience, and gram‐scale production.