丁酸梭菌
代谢组
厚壁菌
生物
微生物学
拟杆菌
细菌
微生物群
普雷沃菌属
乳酸菌
食品科学
生物化学
代谢物
16S核糖体RNA
生物信息学
遗传学
作者
Guofu Li,Tingting Yu,Hong Du,Lichao Zhang,Xiaoxuan Liu,Senlin Hou
标识
DOI:10.1093/jambio/lxad170
摘要
To investigate the function and probable mechanism of Clostridium butyricum in the development of choledocholithiasis.The lithogenic diet group and the lithogenic diet + C. butyricum group were used to develop the choledocholithiasis model. During the experiment, C. butyricum suspension was administered to the rats in the lithogenic diet + C. butyricum group. The findings demonstrated that the C. butyricum intervention decreased the Firmicutes/Bacteroidetes ratio in the colon of experimental animals given a lithogenic diet. The relative levels of Desulfovibrio (0.93%) and Streptococcus (0.38%) fell, whereas Lactobacillus (22.36%), Prevotella (14.09%), and bacteria that produce short-chain fatty acids increased. Finally, 68 distinct metabolic products were found based on nontargeted metabonomics, and 42 metabolic pathways associated to the various metabolites were enriched.We found that C. butyricum decreased the development of choledocholithiasis. It keeps the equilibrium of the rat's gut microbiome intact and lowers the danger of bacterial infections of the gastrointestinal and biliary systems. It is hypothesized that by controlling lipid metabolism, it may also have an impact on the development of cholelithiasis.
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