血红蛋白
氧化应激
生物标志物
氧化磷酸化
范围(计算机科学)
计算生物学
生物
生物信息学
生物化学
计算机科学
程序设计语言
作者
Andrea Scirè,Giulia Casari,Brenda Romaldi,Lidia de Bari,Cinzia Antognelli,Tatiana Armeni
标识
DOI:10.20944/preprints202310.1442.v1
摘要
Hemoglobin is one of the proteins that are more susceptible to S-glutathionylation and the levels of its modified form, glutathionyl hemoglobin, increase in several human pathological conditions. The scope of the present review is to provide knowledge about how hemoglobin is subjected to be S-glutathionylated and how this modification affects its functionality. The different diseases that showed increased levels of glutathionyl hemoglobin and the methods used for its quantification in clinical investigations will be also outlined. Since there is a growing need for precise and reliable methods of markers of oxidative stress in human blood, this review highlights how glutathionyl hemoglobin is more and more emerging as a good indicator of severe oxidative stress but also as a key pathogenic factor in several diseases.
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