HBx公司
病毒复制
乙型肝炎病毒
病毒学
肝细胞癌
病毒结构蛋白
生物
病毒蛋白
乙型肝炎病毒β前体
病毒性肝炎
病毒转化
病毒
癌症研究
乙型肝炎病毒DNA聚合酶
病毒进入
出处
期刊:PubMed
日期:2023-08-01
卷期号:77 (4): 341-345
摘要
Hepatitis B virus is a pathogenic virus that infects 300 million people worldwide and causes chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Hepatitis B virus encodes four proteins. Among them, the HBx protein plays a central role in the HBV pathogenesis. Because the HBx protein is considered to play a central role in the induction of viral replication and hepatocarcinogenesis, the regulation of its function could be a key factor in the development of new interventions against hepatitis B. In this review, HBx protein-related viral replication and hepatocarcinogenesis mechanisms are described, with a focus on the recently reported viral replication mechanisms related to degradation of the Smc5/6 protein complex. We also discuss our recent discovery of a compound that inhibits HBx protein-induced degradation of the Smc5/6 protein complex, and that exerts inhibitory effects on both viral replication and hepatocarcinogenesis. Finally, prospects for future research on the HBx protein are described.
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