DDX20: A Multifunctional Complex Protein

生物 细胞生物学 RNA剪接 先天免疫系统 核糖核酸 转录因子 剪接体 遗传学 免疫系统 基因
作者
He Li,Jinke Yang,Yu Hao,Xing Yang,Xijuan Shi,Dajun Zhang,Dengshuai Zhao,Wenqian Yan,Xintian Bie,Lingling Chen,Guohui Chen,Shufan Zhao,Xiangtao Liu,Haixue Zheng,Keshan Zhang
出处
期刊:Molecules [Multidisciplinary Digital Publishing Institute]
卷期号:28 (20): 7198-7198 被引量:1
标识
DOI:10.3390/molecules28207198
摘要

DEAD-box decapping enzyme 20 (DDX20) is a putative RNA-decapping enzyme that can be identified by the conserved motif Asp–Glu–Ala–Asp (DEAD). Cellular processes involve numerous RNA secondary structure alterations, including translation initiation, nuclear and mitochondrial splicing, and assembly of ribosomes and spliceosomes. DDX20 reportedly plays an important role in cellular transcription and post-transcriptional modifications. On the one hand, DDX20 can interact with various transcription factors and repress the transcriptional process. On the other hand, DDX20 forms the survival motor neuron complex and participates in the assembly of snRNP, ultimately affecting the RNA splicing process. Finally, DDX20 can potentially rely on its RNA-unwinding enzyme function to participate in microRNA (miRNA) maturation and act as a component of the RNA-induced silencing complex. In addition, although DDX20 is not a key component in the innate immune system signaling pathway, it can affect the nuclear factor kappa B (NF-κB) and p53 signaling pathways. In particular, DDX20 plays different roles in tumorigenesis development through the NF-κB signaling pathway. This process is regulated by various factors such as miRNA. DDX20 can influence processes such as viral replication in cells by interacting with two proteins in Epstein–Barr virus and can regulate the replication process of several viruses through the innate immune system, indicating that DDX20 plays an important role in the innate immune system. Herein, we review the effects of DDX20 on the innate immune system and its role in transcriptional and post-transcriptional modification processes, based on which we provide an outlook on the future of DDX20 research in innate immunity and viral infections.
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