压实
过程(计算)
比例(比率)
钥匙(锁)
有限元法
工业工程
计算机科学
工艺工程
工程类
机械工程
生化工程
结构工程
岩土工程
物理
计算机安全
量子力学
操作系统
作者
Keirnan R. LaMarche,David Trinkle,Brian M. Zacour,Sherif Badawy
标识
DOI:10.1016/j.powtec.2023.118528
摘要
A model of the compaction process that has come into increasing use with the pharmaceutical industry is the Drucker-Prager Cap model (DPC). It has long been used in conjunction with the finite element methods to simulate the density and stress distributions in compacts. More recently the calibrated parameters that make up the model have been used to characterize the material properties of many compounds. This work will summarize the findings from the collection of DPC parameters from 60 materials. From this dataset several important conclusions can be drawn about typical and extreme behaviors of formulations and excipients. From these findings key signals of program risk can be determined and utilized early in the formulation development process to avoid costly manufacturing and scale-up issues.
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