Advances in click chemistry for drug discovery and development

Click chemistry serves as a powerful enabler of accelerated drug discovery and development. Nevertheless, its clinical translation faces challenges such as physiological interference, pharmacokinetic requirements, and the potential toxicity of metal catalysts. Going forward, research should prioritize optimizing click chemistry reactions to enhance biocompatibility, safety, and stability. Meanwhile, combining click chemistry with artificial intelligence offers promise for identifying structurally diverse candidate molecules that are also synthetically feasible.