Shoutai Pill synergistically inhibits internal reproductive organ apoptosis: coordinated EGFR/PI3K/AKT modulation in primary ovarian insufficiency

The results indicate that STW effectively restores hormonal homeostasis, ovarian function, and uterine morphology in POI mice. This therapeutic effect may involve inhibition of the ovarian-endometrial cell apoptosis cascade via activation of the EGFR/PI3K/AKT pathway. These findings provide new insights into the molecular mechanisms of POI and support STW as a potential therapeutic strategy targeting the ovary-uterus axis.