Cholesterol-Supported Liquid-Phase Synthesis of Betaines and Organic Cations without Chromatography

Cholesterol was explored as a support for liquid-phase synthesis. Without the need for chromatography, the cholesterol-supported liquid-phase approach gave access to diverse betaines possessing chiral ammonium, phosphonium, and sulfonium ions. The cholesterol-supported method was further demonstrated by the synthesis of cationic amides and hydrazides.