氧化应激
白内障
失明
医学
内质网
糖尿病
白内障手术
生物信息学
细胞生物学
眼科
生物
验光服务
内科学
内分泌学
作者
Jingyan Li,Francesco Buonfiglio,Ying Zeng,Norbert Pfeiffer,Adrian Gericke
出处
期刊:Antioxidants
[Multidisciplinary Digital Publishing Institute]
日期:2024-10-16
卷期号:13 (10): 1249-1249
被引量:32
标识
DOI:10.3390/antiox13101249
摘要
Cataracts, a leading cause of blindness worldwide, are closely linked to oxidative stress-induced damage to lens epithelial cells (LECs). Key factors contributing to cataract formation include aging, arterial hypertension, and diabetes mellitus. Given the high global prevalence of cataracts, the burden of cataract-related visual impairment is substantial, highlighting the need for pharmacological strategies to supplement surgical interventions. Understanding the molecular pathways involved in oxidative stress during cataract development may offer valuable insights for designing novel therapeutic approaches. This review explores the role of oxidative stress in cataract formation, focusing on critical mechanisms, such as mitochondrial dysfunction, endoplasmic reticulum stress, loss of gap junctions, and various cell death pathways in LECs. Additionally, we discuss emerging therapeutic strategies and potential targeting options, including antioxidant-based treatments.
科研通智能强力驱动
Strongly Powered by AbleSci AI