胆汁淤积
再生(生物学)
肝再生
Wnt信号通路
平衡
肝损伤
医学
生物信息学
内科学
生物
细胞生物学
信号转导
作者
Kari Nejak‐Bowen,Singh Monga
出处
期刊:Hepatology
[Wiley]
日期:2023-05-30
卷期号:78 (6): 1907-1921
被引量:1
标识
DOI:10.1097/hep.0000000000000495
摘要
Wnt-β-catenin signaling has emerged as an important regulatory pathway in the liver, playing key roles in zonation and mediating contextual hepatobiliary repair after injuries. In this review, we will address the major advances in understanding the role of Wnt signaling in hepatic zonation, regeneration, and cholestasis-induced injury. We will also touch on some important unanswered questions and discuss the relevance of modulating the pathway to provide therapies for complex liver pathologies that remain a continued unmet clinical need.
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