化学
立体化学
金刚烷
藤黄属
细胞毒性
IC50型
体外
生物化学
有机化学
生物
植物
作者
Cheng-Jun Jia,Jingjing Xue,Zhan‐Lin Li,Dahong Li,Hui‐Ming Hua
标识
DOI:10.1080/14786419.2023.2217469
摘要
Bioassay-guided isolation of the stems of Garcinia paucinervis led to one new adamantane-type polycyclic polyprenylated acylphloroglucinols (PPAPs), (-)-garpauvinin A (1), and four known analogues (2–5). The structure and absolute configuration of 1 was established via spectroscopic techniques and ECD method. All the isolates displayed moderate antiproliferative activity against HL-60, PC-3 and Caco-2 human cancer cell lines with IC50 values ranging from 0.81 to 19.92 μM, and exhibited low toxicity on WPMY-1 normal human cells, showing selectivity between normal and malignant prostate cells. The biosynthetic pathways of the isolated PPAPs were proposed.
科研通智能强力驱动
Strongly Powered by AbleSci AI