Antiproliferative polycyclic polyprenylated acylphloroglucinols from Garcinia paucinervis

AbstractAbstractBioassay-guided isolation of the stems of Garcinia paucinervis led to one new adamantane-type polycyclic polyprenylated acylphloroglucinols (PPAPs), (-)-garpauvinin A (1), and four known analogues (2–5). The structure and absolute configuration of 1 was established via spectroscopic techniques and ECD method. All the isolates displayed moderate antiproliferative activity against HL-60, PC-3 and Caco-2 human cancer cell lines with IC50 values ranging from 0.81 to 19.92 μM, and exhibited low toxicity on WPMY-1 normal human cells, showing selectivity between normal and malignant prostate cells. The biosynthetic pathways of the isolated PPAPs were proposed.Graphical AbstractKeywords: Garcinia paucinervisPPAPsantitumorgarpauvinin A Disclosure statementNo potential conflict of interest was reported by the authors.Additional informationFundingFinancial support by the National Natural Science Foundation of China (31570350 and 82173715) and National Science and Technology Major Project of the Ministry of Science and Technology of China (2018ZX09735005).