E‐cigarette, or Vaping, Product Use Associated Lung Injury: Epidemiology, Challenges, and Implications With COVID‐19

ABSTRACT Background E‐cigarette, or vaping products produce an aerosol by heating nicotine, or cannabis including tetrahydrocannabinol (THC) and cannabidiol (CBD), mixed with other chemicals that help make the aerosol. They are increasingly popular among teenagers and young adults, with a 2023 survey reporting that 2.13 million middle and high school students in the United States used e‐cigarettes within the last 30 days. The use of e‐cigarette, or vaping products could lead to an acute pulmonary inflammatory syndrome called e‐cigarette, or vaping, product use‐associated lung injury (EVALI). We review the challenges in diagnosing and treating EVALI, especially during the COVID‐19 pandemic. Methods We conducted a literature search on June 10, 2024 using the PubMed database. We searched for articles, case reports and CDC reports investigating the pathogenesis, treatment, and challenges of diagnosing EVALI during the COVID‐19 pandemic. Results The exact causes of EVALI are not completely understood, although it has been linked to the use of THC and vitamin E acetate. There are no specific biomarkers to diagnose EVALI and it is typically diagnosed through a process of eliminating other possible conditions. Eight studies detailed cases where pediatric patients were initially diagnosed with COVID‐19 or community‐acquired pneumonia, despite multiple negative COVID‐19 tests, and were later found to have EVALI. Conclusions After alerting the public about the removal of vitamin E acetate from vape liquids in 2020, there has been a decline in cases of EVALI, although they are still detected. Therefore, it is necessary to continue looking for diagnostic markers of EVALI and further investigate the toxicity of vapes and e‐cigarettes to prevent the recurrence of another EVALI epidemic, especially among teenagers and young adults.