绒毛
米诺地尔
头皮
医学
皮肤病科
男性型秃发
毛囊
毛发移植
内科学
作者
A. Keren,R. Paus,Amos Gilhar
标识
DOI:10.1016/j.jid.2022.09.577
摘要
Based on trichogram evidence, it has been claimed that, once terminal (T) scalp hair follicles (HFs) have been fully miniaturized into vellus (V) HFs in androgenetic alopecia (AGA), these cannot be reconverted into T HFs, even under therapy (Rushton et al. Exp Dermatol 2022). If true, this would mandate early intervention in AGA management, and would render hair transplantation the only meaningful therapy for late-stage AGA. Given that hypertrichosis-inducing drugs and hormones can rapidly induce V-T HF conversion, we wished to probe the validity of this provocative postulate by generating irrefutable histological evidence, using our novel humanized AGA mouse model under long-term therapy with minoxidil (MXL) or platelet rich plasma (PRP).
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