孟德尔随机化
医学
冲程(发动机)
混淆
全国健康与营养检查调查
内科学
逻辑回归
观察研究
蛛网膜下腔出血
横断面研究
物理疗法
环境卫生
病理
基因型
人口
机械工程
生物化学
化学
遗传变异
工程类
基因
作者
Rundong Chen,Hanchen Liu,Guanghao Zhang,Qian Zhang,Weilong Hua,Lei Zhang,Nan Lv,Yilei Zhang,Dongwei Dai,Rui Zhao,Qiang Li,Qinghai Huang,Yi Xu,Pengfei Yang,Jianmin Liu,Qiao Zuo
标识
DOI:10.1186/s40001-024-01646-5
摘要
Stroke is the second leading cause of death worldwide, and observational studies have suggested a correlation between antioxidants and reduced stroke risk. However, it remains unclear whether causal relationships exist.This study first performed a cross-sectional study of the association between the Composite Dietary Antioxidant Index (CDAI) and stroke using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. Second, a two-sample univariable Mendelian Randomization (MR) was performed to analyze the causal effect of circulating levels of antioxidants on different subtypes of stroke.The cross-sectional study included a total of 24,892 participants representing more than 200 million US non-institutionalized residents, a multivariable logistic regression model revealed that the risk of stroke decreased by 3.4% for each unit increase in CDAI (P = 0.017), with a non-linear association found, indicating a reduction in stroke risk before an inflection point of 3.078. MR analysis revealed that genetically determined levels of retinol had a suggestive protective effect on subarachnoid hemorrhage (SAH) (OR = 0.348, P = 0.025), and genetically determined levels of selenium had a suggestive protective effect against SAH (OR = 0.826, P = 0.007). However, no causal relationship was found between antioxidants and ischemic stroke or intracranial hemorrhage risk.Evidence suggests that diet-derived antioxidants may reduce the risk of stroke, as indicated by the protective effects of retinol and selenium against SAH. However, more research is needed to fully understand how antioxidants prevent stroke.
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