蛋白酵素
清脆的
计算生物学
化学
生物
遗传学
生物化学
酶
基因
作者
Sam P. B. van Beljouw,Stan J. J. Brouns
出处
期刊:Biochemical Society Transactions
[Portland Press]
日期:2024-02-09
摘要
With the discovery of CRISPR-controlled proteases, CRISPR–Cas has moved beyond mere nucleic acid targeting into the territory of targeted protein cleavage. Here, we review the understanding of Craspase, the best-studied member of the growing CRISPR RNA-guided protease family. We recollect the original bioinformatic prediction and early experimental characterizations; evaluate some of the mechanistic structural intricacies and emerging biotechnology; discuss open questions and unexplained mysteries; and indicate future directions for the rapidly moving field of the CRISPR proteases.
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