生物合成
材料科学
癌症研究
放射治疗
DNA损伤
癌症
癌症治疗
纳米技术
DNA
生物医学工程
基因
生物化学
医学
化学
内科学
作者
Zi Fu,Zhuang Liu,Jiaxing Wang,Lianfu Deng,Han Wang,Wei Tang,Dalong Ni
出处
期刊:Biomaterials
[Elsevier]
日期:2023-04-01
卷期号:295: 122035-122035
被引量:7
标识
DOI:10.1016/j.biomaterials.2023.122035
摘要
Radiation therapy (RT) is one of the most widely used cancer treatments. However, the vigorous biosynthesis of cancer cells plays an important role for RT resistance. Herein, we develop a hafnium-based nanoscale metal-organic frameworks (Hf-nMOFs) loaded with 3-bromopyruvate (3-BrPA) to overcome RT resistance and achieve favorable RT efficacy. The deposition of X-rays is greatly enhanced by Hf-nMOFs to induce stronger damage to DNA in RT. Simultaneously, as an inhibitor of glycolysis, the loaded 3-BrPA can reduce the supply of energy and interfere with the biosynthesis of proteins to decrease the DNA damage repair. As a result, the 3-BrPA@Hf-nMOFs (BHT) will overcome the RT resistance and enhance the curative effect of RT. Up and down-regulated genes as well as the related pathways in cellular metabolism and biosynthesis are well investigated to reveal the radiosensitization mechanism of BHT. In addition, the Hf element endows BHT with CT imaging capability to real-timely monitor the therapeutic process. Hence, the designed strategy of biosynthesis-targeted radiosensitization could decrease the doses of ionizing radiations and provide fresh perspectives on cancer treatment.
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