表型
转化(遗传学)
神经内分泌肿瘤
机制(生物学)
垂体瘤
恶性转化
生物
肿瘤转化
生物信息学
医学
病理
基因
癌症研究
遗传学
癌变
哲学
认识论
作者
Zhenwei Li,Yanjiao Wu,Guannan He,Renzhi Wang,Xinjie Bao
出处
期刊:Cancers
[Multidisciplinary Digital Publishing Institute]
日期:2024-04-29
卷期号:16 (9): 1731-1731
标识
DOI:10.3390/cancers16091731
摘要
Phenotype transformation in pituitary neuroendocrine tumors is a little-known and unpredictable clinical phenomenon. Previous studies have not clearly defined and systematically concluded on the causes of this rare phenomenon. Additionally, the mechanisms of phenotype transformation are not well known. We reviewed cases reported in the literature with the aim of defining phenotype transformation in pituitary neuroendocrine tumors. We present an overview of the wide spectrum of phenotype transformation and its clinical features. We also discuss findings on the potential mechanism of this rare transformation, which may be related to PC1/3, the bioactivity of secretory hormones, gene mutations and the plasticity of pituitary neuroendocrine tumors. Clinicians should be aware of this rare phenomenon and more studies on the underlying mechanisms are required.
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