Phenolic Bisabolanes from the Marine-Derived Fungus Aspergillus sp. MEA11

The deep sea sediment-derived fungus Aspergillus sp.MEA11 was examined for secondary metabolites.Chromatographic separations resulted in the identification of a new phenolic bisabolane (1) and seven known analogs (3-7 and 8a, 8b).The structures were determined by 1 H, 13 C NMR, and MS data.The known compounds were identified to be 11,12-dihydroxysydonic acid (2), hydroxysydonic acid (3), aspergoterpenin B (4), engyodontiumone J (5), sydowic acid (6), penicipyran A (7), 1-hydroxyboivinianic acid (8).The NMR data of 7 in methanol-d4 were reported for the first time.Compounds 6-8 exhibited inhibitory effect against -glucosidase with IC50 values of 176, 89, 232 M, respectively, which were more active than the positive control acabose.