Abstract 10212: Exposure to Volatile Organic Compounds - Acrolein, Crotonaldehyde, and Styrene - is Associated with Blood Pressure in the Jackson Heart Study

HomeCirculationAbstract 10212: Exposure to Volatile Organic Compounds - Acrolein, Crotonaldehyde, and Styrene - is Associated with Blood Pressure in the Jackson Heart Study Free AccessAbstractAboutSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractEpidemiology, Big Data and Precision MedicineSession Title: Evolving Epidemiology of Hypertension and Blood Pressure ManagementAbstract 10212: Exposure to Volatile Organic Compounds - Acrolein, Crotonaldehyde, and Styrene - is Associated with Blood Pressure in the Jackson Heart Study Katlyn E McGraw, Stacey L Konkle, Daniel W Riggs, Shesh N Rai, Natasha K DeJarnett, Zhengzhi Xie, Adebamike A Oshunbade, Rachel J Keith, Michael E Hall and Aruni Bhatnagar Katlyn E McGrawKatlyn E McGraw Environmental Health Sciences, Columbia Univ, New York City, NY , Stacey L KonkleStacey L Konkle Epidemiology, Univ of Louisville, Louisville, KY , Daniel W RiggsDaniel W Riggs Epidemiology, Univ of Louisville, Louisville, KY , Shesh N RaiShesh N Rai Univ of Louisville, Louisville, KY , Natasha K DeJarnettNatasha K DeJarnett Envirome, Univ of Louisville, Louisville, KY , Zhengzhi XieZhengzhi Xie Envirome, Univ of Louisville, Louisville, KY , Adebamike A OshunbadeAdebamike A Oshunbade Univ of Mississippi Med C, Jackson, MS , Rachel J KeithRachel J Keith Univ of Louisville, Louisville, KY , Michael E HallMichael E Hall Univ of Mississippi Med Cntr, Jackson, MS and Aruni BhatnagarAruni Bhatnagar Univ of Louisville, Louisville, KY Originally published8 Nov 2021https://doi.org/10.1161/circ.144.suppl_1.10212Circulation. 2021;144:A10212AbstractIntroduction: Cardiovascular disease (CVD) is the leading cause of death from environmental exposures. Although exposure to particulate matter ≤2.5μm (PM2.5) is an established risk factor for CVD, the contribution of other hazardous pollutant exposure to CVD risk is less clear.Hypothesis: We assessed the hypothesis that volatile organic compounds (VOCs) are associated with blood pressure in 778 nonsmokers from the Jackson Heart Study (JHS), a large, community based observational study of CVD in African Americans from the tri-county Jackson, MS area.Methods: We measured urinary metabolites of 17 parent VOCs in spot urine samples collected at baseline using UPLC/MS. We tested the association between VOC metabolites and blood pressure in nonsmokers using generalized linear models adjusted for age, sex, body mass index (BMI), estimated glomerular filtration rate, cholesterol to high-density lipoprotein ratio, triglycerides, blood pressure medications, diabetes, and PM2.5. Two measurements of systolic and diastolic blood pressure (SBP, DBP) in the resting state were averaged using a Hawksley random zero sphygmomanometer.Results: Included participants had a BMI of 31.3 ± 7.1 kg/m2 (mean ± SD), had triglycerides of 99.9 ± 57.9 mg/dL, and a less than 10% prevalence of CVD events. More than one-third were affluent (37.8%) and almost half used blood pressure medications (46%). We found that metabolites of acrolein (CEMA) and crotonaldehyde (HPMMA) were associated with a 1.5mmHg (CI: 0.5, 2.7; p=0.01), and a 1.1mmHg higher (CI: 0.1, 2.0; p=0.02) SBP per interquartile range (IQR) of VOC metabolite, respectively. Additionally, we found a 0.5mmHg higher (CI: 0.1, 0.8; p= 0.01) DBP per IQR of styrene metabolite, MA. In subgroup analysis, the association between CEMA and MA and blood pressure persisted only in men.Conclusions: In conclusion, these findings suggest that exposure to VOCs (acrolein, crotonaldehyde, and styrene) may be a significant contributor to risk of hypertension among African American nonsmokers.FootnotesAuthor Disclosures: For author disclosure information, please visit the AHA Scientific Sessions 2021 Online Program Planner and search for the abstract title. eLetters(0) eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate. Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page. Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsCited By Johnston J, Quist A, Navarro S, Farzan S and Shamasunder B (2023) Cardiovascular health and proximity to urban oil drilling in Los Angeles, California, Journal of Exposure Science & Environmental Epidemiology, 10.1038/s41370-023-00589-z November 16, 2021Vol 144, Issue Suppl_1 Advertisement Article Information Metrics © 2021 by American Heart Association, Inc.https://doi.org/10.1161/circ.144.suppl_1.10212 Originally publishedNovember 8, 2021 KeywordsBlood pressureEpidemiologyRaceAir pollutionGender differences Advertisement