已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Characteristics of myasthenia gravis in elderly patients: a retrospective study

重症肌无力 胸腺瘤 医学 危险系数 内科学 置信区间 回顾性队列研究 神经学 入射(几何) 队列 胸腺切除术 风险因素 儿科 外科 物理 光学 精神科
作者
Yi Li,Xiaohua Dong,Zhibin Li,Yuyao Peng,Wanlin Jin,Ran Zhou,Fei Jiang,Liqun Xu,Zhaohui Luo,Huan Yang
出处
期刊:Neurological Sciences [Springer Science+Business Media]
卷期号:43 (4): 2775-2783 被引量:9
标识
DOI:10.1007/s10072-021-05599-z
摘要

Background The incidence of myasthenia gravis (MG) is increasing, and its characteristics in elderly patients are believed to differ from those in younger patients. However, only a few studies have focused on elderly patients with MG. Objective To review the characteristics of MG in elderly patients and evaluate whether older age is an independent factor associated with achieving minimal manifestation status (MMS). Methods This retrospective cohort study included 367 patients (319 non-elderly and 48 elderly patients) with MG enrolled at Xiangya Hospital from September 1, 2016, to December 31, 2018. We collected demographic data and information regarding comorbidities, antibody status, Myasthenia Gravis Foundation of America classification, affected muscle groups, thymoma, and treatment. MMS was defined as the primary outcome. Results Comorbidities were more common in elderly than in younger patients with MG. Anti-acetylcholine receptor antibody was the dominant subtype, whereas anti-muscle-specific tyrosine kinase antibody was rare and detected only in non-elderly patients. Elderly patients were more likely than younger patients to have generalized MG, but the frequency of thymoma was lower (28.5% vs. 10.4%, p = 0.0078). MMS or better was achieved in 154 (48.3%) and 13 (27.1%) non-elderly and elderly patients, respectively. Older age did not appear to be an independent factor associated with MMS (hazard ratio = 0.625; 95% confidence interval, 0.345-1.131). Conclusions Older age was not an independent factor for a worse prognosis in patients with MG. The treatment of elderly patients with MG should be individually tailored.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
万能图书馆应助晨曦微露采纳,获得10
刚刚
木语完成签到 ,获得积分20
刚刚
Newky发布了新的文献求助10
刚刚
1秒前
研友_5Y9Z75完成签到 ,获得积分0
2秒前
Cyber完成签到,获得积分20
4秒前
科研通AI5应助Cyber采纳,获得10
8秒前
卷卷完成签到 ,获得积分10
8秒前
深秋远塞完成签到,获得积分10
9秒前
10秒前
10秒前
acheeee完成签到,获得积分10
13秒前
隐形曼青应助Yummy采纳,获得10
15秒前
晨曦微露发布了新的文献求助10
16秒前
科目三应助Newky采纳,获得10
17秒前
晓雨完成签到 ,获得积分10
21秒前
清秀灵薇完成签到,获得积分10
23秒前
晨曦微露完成签到,获得积分10
26秒前
27秒前
aa完成签到,获得积分10
32秒前
37秒前
暴躁的鸿涛完成签到,获得积分10
37秒前
orixero应助aa采纳,获得10
38秒前
LSL丶完成签到,获得积分10
39秒前
头孢西丁完成签到 ,获得积分10
40秒前
Shiku完成签到,获得积分10
40秒前
Yummy发布了新的文献求助10
41秒前
生物小白完成签到,获得积分10
42秒前
YOYO完成签到,获得积分10
48秒前
晓书完成签到 ,获得积分10
49秒前
大喵发布了新的文献求助20
52秒前
QQ发布了新的文献求助10
55秒前
了晨完成签到 ,获得积分10
57秒前
大学生完成签到 ,获得积分10
59秒前
科研通AI5应助科研通管家采纳,获得10
1分钟前
1分钟前
1分钟前
苹果笑寒完成签到 ,获得积分10
1分钟前
小张同学完成签到 ,获得积分10
1分钟前
1分钟前
高分求助中
Les Mantodea de Guyane Insecta, Polyneoptera 2500
Mobilization, center-periphery structures and nation-building 600
Introduction to Strong Mixing Conditions Volumes 1-3 500
Technologies supporting mass customization of apparel: A pilot project 450
China—Art—Modernity: A Critical Introduction to Chinese Visual Expression from the Beginning of the Twentieth Century to the Present Day 430
Multichannel rotary joints-How they work 400
A Field Guide to the Amphibians and Reptiles of Madagascar - Frank Glaw and Miguel Vences - 3rd Edition 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3795475
求助须知:如何正确求助?哪些是违规求助? 3340512
关于积分的说明 10300384
捐赠科研通 3057032
什么是DOI,文献DOI怎么找? 1677368
邀请新用户注册赠送积分活动 805385
科研通“疑难数据库(出版商)”最低求助积分说明 762491