立体中心
对映选择合成
化学
催化作用
不对称氢化
氮原子
组合化学
过渡金属
有机化学
戒指(化学)
作者
Albert Cabré,Xavier Verdaguer,Antoni Riéra
出处
期刊:Chemical Reviews
[American Chemical Society]
日期:2021-10-22
卷期号:122 (1): 269-339
被引量:152
标识
DOI:10.1021/acs.chemrev.1c00496
摘要
Chiral amines are key structural motifs present in a wide variety of natural products, drugs, and other biologically active compounds. During the past decade, significant advances have been made with respect to the enantioselective synthesis of chiral amines, many of them based on catalytic asymmetric hydrogenation (AH). The present review covers the use of AH in the synthesis of chiral amines bearing a stereogenic center either in the α, β, or γ position with respect to the nitrogen atom, reported from 2010 to 2020. Therefore, we provide an overview of the recent advances in the AH of imines, enamides, enamines, allyl amines, and N-heteroaromatic compounds.
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