普鲁士蓝
光热治疗
癌细胞
体内
癌症
材料科学
纳米技术
生物物理学
癌症研究
纳米颗粒
化学
生物
生物技术
物理化学
遗传学
电化学
电极
作者
Pei Wang,Ranjith Kumar Kankala,Biao‐Qi Chen,Yang Zhang,Mingzhi Zhu,Xuemei Li,Ruimin Long,Dayun Yang,Rumen Krastev,Shibin Wang,Xin Xiong,Yuangang Liu
标识
DOI:10.1021/acsami.1c11138
摘要
Despite its success against cancer, photothermal therapy (PTT) (>50 °C) suffers from several limitations such as triggering inflammation and facilitating immune escape and metastasis and also damage to the surrounding normal cells. Mild-temperature PTT has been proposed to override these shortcomings. We developed a nanosystem using HepG2 cancer cell membrane-cloaked zinc glutamate-modified Prussian blue nanoparticles with triphenylphosphine-conjugated lonidamine (HmPGTL NPs). This innovative approach achieved an efficient mild-temperature PTT effect by downregulating the production of intracellular ATP. This disrupts a section of heat shock proteins that cushion cancer cells against heat. The physicochemical properties, anti-tumor efficacy, and mechanisms of HmPGTL NPs both in vitro and in vivo were investigated. Moreover, the nanoparticles cloaked with the HepG2 cell membrane substantially prolonged the circulation time in vivo. Overall, the designed nanocomposites enhance the efficacy of mild-temperature PTT by disrupting the production of ATP in cancer cells. Thus, we anticipate that the mild-temperature PTT nanosystem will certainly present its enormous potential in various biomedical applications.
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