材料科学
激光器
玻璃体切除术
生物物理学
辐照
碳纤维
视网膜
化学
生物医学工程
复合材料
眼科
光学
医学
视力
复合数
物理
核物理学
生物
作者
Alexandre Barras,Félix Sauvage,Inès De Hoon,Kevin Braeckmans,Dawei Hua,Gaëtan Buvat,Juan C. Fraire,Christophe Lethien,J. Sebag,Michael G. Harrington,Amar Abderrahmani,Rabah Boukherroub,Stefaan De Smedt,Sabine Szunerits
出处
期刊:Nanoscale horizons
[The Royal Society of Chemistry]
日期:2021-01-01
卷期号:6 (6): 449-461
被引量:13
摘要
Common in myopia and aging, vitreous opacities arise from clumped collagen fibers within the vitreous body that cast shadows on the retina, appearing as 'floaters' to the patient. Vitreous opacities degrade contrast sensitivity function and can cause significant impairment in vision-related quality-of-life, representing an unmet and underestimated medical need. One therapeutic approach could be the use of versatile light-responsive nanostructures which (i) interfere with the formation of collagen fibers and/or (ii) destroy aggregates of vitreous collagen upon pulsed-laser irradiation at low fluences. In this work, the potential of positively and negatively charged carbon quantum dots (CQDs) to interfere with the aggregation of type I collagen is investigated. We demonstrate that fibrillation of collagen I is prevented most strongly by positively charged CQDs (CQDs-2) and that pulsed-laser illumination allowed to destroy type I collagen aggregates and vitreous opacities (as obtained from patients after vitrectomy) treated with CQDs-2.
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