脚手架
骨整合
材料科学
3d打印
钛
生物医学工程
表面改性
间充质干细胞
热喷涂
多孔性
电化学
模拟体液
纳米技术
化学工程
植入
化学
复合材料
涂层
扫描电子显微镜
冶金
外科
电极
物理化学
工程类
细胞生物学
医学
生物
作者
Yang Kook Sun,Xing Zhang,Mingran Luo,Weifan Hu,Li Wu Zheng,Ru‐Qi Huang,Johannes Greven,Falk Hildebrand,Feng Yuan
标识
DOI:10.3389/fbioe.2021.705774
摘要
Surface modification of three-dimensional (3D)-printed titanium (Ti) scaffolds with hydroxyapatite (HA) has been a research hotspot in biomedical engineering. However, unlike HA coatings on a plain surface, 3D-printed Ti scaffolds have inherent porous structures that influence the characteristics of HA coatings and osteointegration. In the present study, HA coatings were successfully fabricated on 3D-printed Ti scaffolds using plasma spray and electrochemical deposition, named plasma sprayed HA (PSHA) and electrochemically deposited HA (EDHA), respectively. Compared to EDHA scaffolds, HA coatings on PSHA scaffolds were smooth and continuous. In vitro cell studies confirmed that PSHA scaffolds have better potential to promote bone mesenchymal stem cell adhesion, proliferation, and osteogenic differentiation than EDHA scaffolds in the early and late stages. Moreover, in vivo studies showed that PSHA scaffolds were endowed with superior bone repair capacity. Although the EDHA technology is simpler and more controllable, its limitation due to the crystalline and HA structures needs to be improved in the future. Thus, we believe that plasma spray is a better choice for fabricating HA coatings on implanted scaffolds, which may become a promising method for treating bone defects.
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