Cell Proliferation, Survival, Necrosis and Apoptosis

There areFundamental cellular processes fundamental cellular processesCellular processes, such as proliferation, survival, necrosisNecrosis and apoptosisApoptosis that play a role in physiological and pathological processes. These pathways are described and discussed in the light of cell mechanicsCell mechanics. In this chapter, the concept of mechanical cell competitionMechanical cell competition through introducing the key parameters governs the control of competitive interactions and also introduces latest advances in the presentation of the signal transduction pathwaysSignal transduction pathways, which regulates compaction-triggered cell deathCell death. Thereafter, the relationship between mechanical cell competitionMechanical cell competition and other mechanisms of cellular competition is presented. Moreover, a focus is on the relevance of mechanical cell competition during the initiation of tumors and their progression, whereby the effect of the mechanical microenvironmentMicroenvironment is included and related to tumor growth, and the effect of residual stress on tumor progression and the intratumoral competition is discussed.