HYALURONIDASE OINTMENT IN TREATMENT OF HYPERTROPHIC SCARS.

We have studied efficiency of hyaluronidase ointment created on the base of microbial hyaluronidase preparation "Bilidase" in treatment of postoperative hypertrophic scars. A total number of 14 patients with postoperative hypertrophic scars on different part of face were enrolled in the study. All patients were treated with hyaluronidase ointment by help of iontophoresis for 10 days -1 procedure per day and than retreated 1 time with the same regimen at 4-week interval. Scar conditions were assessed in terms of pigmentation, vascularity, pliability, height, pain and pruritis in accordance with the Vancouver Scar Scale (VSS). The data of this investigation indicate that treatment of postoperative scars with hyaluronidase ointment significantly improves the function as well as a cosmetic appearance of scar tissues. Each of the investigated parameters was improved significantly after hyaluronidase treatment. Total score after 1 cycle of treatment was 5.14±0.9 vs 10±1.5 before treatment and after 2 cycles of treatment. total score was 0.85±0.9 vs 10±1.5 before treatment (p<0.001). Hyaluronidase ointment could also be recommended for preventing the scar formation in plastic surgery.