光敏剂
化学
石墨氮化碳
光动力疗法
光化学
可见光谱
光子上转换
紫外线
活性氧
量子点
纳米颗粒
单线态氧
纳米技术
光电子学
光催化
氧气
材料科学
催化作用
离子
有机化学
生物化学
作者
Ming‐Hsien Chan,Chieh-Wei Chen,I-Jung Lee,Yin-Ching Chan,Datao Tu,Michael Hsiao,Chung-Hsuan Chen,Xueyuan Chen,Ru‐Shi Liu
出处
期刊:Inorganic Chemistry
[American Chemical Society]
日期:2016-09-26
卷期号:55 (20): 10267-10277
被引量:70
标识
DOI:10.1021/acs.inorgchem.6b01522
摘要
Photodynamic therapy (PDT) is a promising antitumor treatment that is based on photosensitizers. This therapy kills cancer cells by generating reactive oxygen species (ROS) after irradiation with specific laser wavelengths. Being a potential photosensitizer, graphitic carbon nitride (g-C3N4) quantum dots (QDs) are noncytotoxic. Although the use of g-C3N4 QDs is challenged by the limited tissue penetration of UV light, g-C3N4 QDs display excellent ultraviolet (UV) light-triggered cytotoxicity. The g-C3N4 QDs were synthesized using a solid-phase hydrothermal method. The well-distributed hydrophilic g-C3N4 can be combined with NaYF4:Yb3+/Tm3+ upconversion nanoparticles via the positive ligand poly(l-lysine) to produce the final nanocomposite, NaYF4:Yb/Tm-PLL@g-C3N4. Upconversion nanoparticles can transfer IR light into UV light and promote g-C3N4 to release blue-to-green visible light to generate different images. Moreover, g-C3N4 is a promising photosensitizer in PDT because g-C3N4 can transfer oxygen into toxic ROS. The singlet oxygen formed by g-C3N4 displays great potential for use in the treatment of cancer.
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