Mechanisms of Action, Resistance and Toxicity of Insecticides Targeting GABA Receptors

同色 变构调节 氯离子通道 GABA受体 药理学 化学 γ-氨基丁酸 蛋白质亚单位 受体 γ-氨基丁酸受体 生物 生物化学 基因
作者
Steven D. Buckingham,Makoto Ihara,David B. Sattelle,Kazuhiko Matsuda
出处
期刊:Current Medicinal Chemistry [Bentham Science Publishers]
卷期号:24 (27) 被引量:80
标识
DOI:10.2174/0929867324666170613075736
摘要

γ-Aminobutyric acid (GABA) receptors play a central role in fast inhibitory neurotransmission in insects. Several classes of insecticides targeting insect GABA-gated chloride channels have been developed. The important resistant to dieldrin GABA receptor subunit (RDL) has been used to investigate insecticide sites of action using radioligands, electrophysiology and site-directed mutagenesis. Although this important subunit readily forms robust functional homomeric receptors when expressed, alternative splicing and RNA A-to-I editing can generate diverse forms of the receptor.We have reviewed studies on native and recombinant insect GABA-gated chloride channels, their interactions with ligands acting at orthosteric and allosteric sites and their interactions with insecticides. Since some GABA receptor modulators act on L-glutamate-gated chloride channels, some comparisons are included.The actions on GABA-gated chloride channels of polychlorocycloalkanes, cyclodienes, macrocyclic lactones, phenylpyrazoles, isoxazolines, and metadiamides are described and the mechanisms of action of members of these insecticide classes are addressed. Mutations that lead to resistance are discussed as they can be important in developing field diagnostic tests. Toxicity issues relating to insecticides targeting GABA-gated chloride channels are also addressed. An overview of all major insecticide classes targeting insect GABA-gated chloride channels has enhanced our understanding of these important receptors and their insecticide binding sites. However, the subunit composition of native GABA receptors remains unknown and studies to clarify this are needed. Also, the precise sites of action of the recently introduced isoxazolines and meta-diamides will be of interest to pursue.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
zzz发布了新的文献求助30
1秒前
长江长完成签到,获得积分10
1秒前
阿卓卓宇宙最可爱完成签到,获得积分20
2秒前
英姑应助qsxy采纳,获得10
4秒前
蓝多多应助有为采纳,获得20
5秒前
5秒前
6秒前
6秒前
6秒前
7秒前
echo完成签到 ,获得积分10
8秒前
MrTStar发布了新的文献求助30
9秒前
9秒前
生命科学的第一推动力完成签到 ,获得积分10
10秒前
11秒前
13秒前
humorlife完成签到,获得积分10
13秒前
loulan完成签到,获得积分10
13秒前
zycdx3906发布了新的文献求助10
14秒前
14秒前
帅气凝云发布了新的文献求助10
16秒前
喵喵666完成签到,获得积分10
17秒前
catherine完成签到,获得积分10
17秒前
wanci应助澳大利亚采纳,获得10
19秒前
桐桐应助白樱恋曲采纳,获得10
19秒前
D调的华丽完成签到,获得积分10
20秒前
是猪毛啊完成签到,获得积分10
21秒前
cc发布了新的文献求助10
22秒前
汉堡包应助可乐采纳,获得10
22秒前
22秒前
科研通AI2S应助帅气凝云采纳,获得10
22秒前
啊啊啊啊啊完成签到,获得积分20
24秒前
24秒前
25秒前
再休息一分钟完成签到,获得积分10
25秒前
26秒前
完美怀亦发布了新的文献求助10
27秒前
28秒前
小团子发布了新的文献求助10
28秒前
29秒前
高分求助中
【重要!!请各位用户详细阅读此贴】科研通的精品贴汇总(请勿应助) 10000
Semantics for Latin: An Introduction 1055
Plutonium Handbook 1000
Three plays : drama 1000
Psychology Applied to Teaching 14th Edition 600
Robot-supported joining of reinforcement textiles with one-sided sewing heads 600
Cochrane Handbook for Systematic Reviews ofInterventions(current version) 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4101040
求助须知:如何正确求助?哪些是违规求助? 3638835
关于积分的说明 11531360
捐赠科研通 3347581
什么是DOI,文献DOI怎么找? 1839713
邀请新用户注册赠送积分活动 906964
科研通“疑难数据库(出版商)”最低求助积分说明 824156