雷公藤醇
胰腺癌
癌症研究
医学
PLGA公司
胰腺
体内
乙二醇
药理学
药物输送
全身给药
癌症
化学
内科学
细胞凋亡
体外
生物
生物化学
有机化学
生物技术
作者
Xi Cao,Ying Hu,Shuang Luo,Yuejing Wang,Tao Gong,Xun Sun,Yao Fu,Zhirong Zhang
标识
DOI:10.1016/j.apsb.2018.12.009
摘要
Due to the critical correlation between inflammation and carcinogenesis, a therapeutic candidate with anti-inflammatory activity may find application in cancer therapy. Here, we report the therapeutic efficacy of celastrol as a promising candidate compound for treatment of pancreatic carcinoma via naïve neutrophil membrane-coated poly(ethylene glycol) methyl ether-block-poly(lactic-co-glycolic acid) (PEG-PLGA) nanoparticles. Neutrophil membrane-coated nanoparticles (NNPs) are well demonstrated to overcome the blood pancreas barrier to achieve pancreas-specific drug delivery in vivo. Using tumor-bearing mice xenograft model, NNPs showed selective accumulations at the tumor site following systemic administration as compared to nanoparticles without neutrophil membrane coating. In both orthotopic and ectopic tumor models, celastrol-loaded NNPs demonstrated greatly enhanced tumor inhibition which significantly prolonged the survival of tumor bearing mice and minimizing liver metastases. Overall, these results suggest that celastrol-loaded NNPs represent a viable and effective treatment option for pancreatic carcinoma.
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