Intermolecular 1,4‐Carboamination of Conjugated Dienes Enabled by Cp*RhIII‐Catalyzed C−H Activation

Abstract A protocol for the three‐component 1,4‐carboamination of dienes is described. Synthetically versatile Weinreb amides were coupled with 1,3‐dienes and readily available dioxazolones as the nitrogen source using [Cp*RhCl 2 ] 2 ‐catalyzed C−H activation to deliver the 1,4‐carboaminated products. This transformation proceeds under mild reaction conditions and affords the products with high levels of regio‐ and E ‐selectivity. Mechanistic investigations suggest an intermediate Rh III –allyl species is trapped by an electrophilic amidation reagent in a redox‐neutral fashion.