艾瑞布林
医学
转移性乳腺癌
肿瘤科
乳腺癌
内科学
机制(生物学)
癌症
作用机理
动作(物理)
哲学
体外
化学
生物化学
物理
认识论
量子力学
作者
Joyce O’Shaughnessy,Virginia Kaklamani,Kevin Kalinsky
出处
期刊:Future Oncology
[Future Medicine]
日期:2019-05-01
卷期号:15 (14): 1641-1653
被引量:14
标识
DOI:10.2217/fon-2018-0936
摘要
Eribulin is a novel microtubule inhibitor with mitotic and nonmitotic mechanisms of action. Both pooled and subgroup analyses from large-scale Phase III clinical trials demonstrated that eribulin has substantial activity in patients with pretreated (anthracycline and a taxane) advanced or metastatic breast cancer. We review recent pharmacological and clinical findings pertaining to eribulin use in metastatic breast cancer – particularly highlighting eribulin in difficult-to-treat and aggressive disease, and safety data in specific patient populations. Additionally, recent advancements in our understanding of the mechanism of action of eribulin and potential future directions for its clinical development are discussed. Ongoing studies of eribulin in combination with immunotherapies and established cytotoxic agents may help shape the future landscape of breast cancer treatment.
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