Evaluation of singlet oxygen luminescence of a novel chlorin photosensitizer

Photodynamic therapy (PDT) utilizes the combined action of photosensitizer, light and molecular oxygen to generate singlet oxygen to treat various diseases. Photosensitizer is a key component and its optical properties and singlet oxygen quantum yield determine the effectiveness of its photodynamic reaction. This study evaluated the singlet oxygen production of a novel water solubility chlorin photosensitizer - namely YLG-I, which was developed in China. The absorption spectra and singlet oxygen luminescence different solvents were evaluated. It was estimated that the singlet oxygen quantum yield of the new photosensitizer YLG-I was at the same level of the potent chlorin sensitizer mTHPC. Preliminary evaluation suggested that YLG-I was a promising photosensitizer for PDT. This presentation will report the detection of singlet oxygen luminescence of the newly developed PDT sensitizer.