Simple and Efficient Synthesis of Belinostat

Abstract A novel synthesis of belinostat (1) starting from 3-nitrobenzaldehyde has been developed. The key step in this sequence involves the conversion of (2E)-3-(3-aminophenyl)acrylic acid methyl ester to (2E)-3-(3-chlorosulfonylphenyl)acrylic acid methyl ester via diazotization and sulfonylation. Keywords: Belinostatsulfonylationsynthesis ACKNOWLEDGMENT This work was supported by funding from the China Pharmaceutical University (No. 211080).