Secondary metabolites with anti-inflammatory activity isolated from a marine-derived fungus Biscogniauxia sp. 8703

Four new compounds (1-4), along with 22 known metabolites (5-26), were isolated from the fungus Biscogniauxia sp. 8703. The structures of the new compounds were elucidated based on NMR, MS, and ECD analysis. Compounds 1 and 2 were identified as heliannuol D analogs, which exhibited anti-inflammatory activity by inhibiting NO production in LPS-induced RAW 264.7 cell, with IC₅₀ values of 7.14 and 25.25 μM, respectively.