CSF from amyotrophic lateral sclerosis patients applied to motor neurons in culture fails to alter neuron‐specific enolase

Immunoreactivity of neuron-specific enolase was measured in cultured embryonic rat motor neurons as an index of neuronal health. Treatment with cerebrospinal fluid from patients with amyotrophic lateral sclerosis and other neuromuscular disorders had no effect on neuron-specific enolase.