电泳剂
化学
催化作用
级联
联轴节(管道)
药物化学
组合化学
有机化学
机械工程
色谱法
工程类
作者
Yang Wen,Xiangtao Kong,Hong‐Chao Liu,Cui‐Tian Wang,Wan‐Xu Wei,Bin Wang,Xue-Yuan Liu,Yong‐Min Liang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-03-21
卷期号:24 (12): 2399-2403
被引量:10
标识
DOI:10.1021/acs.orglett.2c00666
摘要
An innovative 1,5-HAT cascade strategy has been advanced for the nickel-catalyzed distal arylation via cross-electrophile coupling. Through specific migration, the remote C(sp3)-H bond is regioselectively activated, and Ar-I as the available electrophile is used for the construction of the C(sp3)-C(sp2) bond. This method also has broad applicability for benzylic and aliphatic N-fluorocarboxamides with yields up to 80%. Furthermore, a series of control experiments demonstrated that this reaction is probably initiated by a radical process.
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