SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL CHALCONE AND PYRAZOLINE DERIVATIVES

A series of some novel chalcones and pyrazolines were synthesized and evaluated against bacterial strains such as S.aureus, E.coli, P.aeroginosa and B.subtilis and fungal strains like C.albicans, S.cerevisiae. In the present investigation, substituted chalcones (3a-f) were synthesized by condensing 3-acetyl-2,5-dimethyl thiophene (1) with substituted aromatic aldehydes (2). Then (3a-f) were treated with phenyl hydrazine (4) to yield substituted pyrazolines (5a-f). All the synthesized compounds were characterized by spectral analysis [IR, H-NMR, Mass]. All the compounds were screened for their antibacterial and antifungal activity, Zone of Inhibition (ZOI) was determined and most of the compounds were shown significant activity against bacteria when compared to fungal organisms.