纳米棒
纳米晶
化学
免疫系统
材料科学
纳米技术
抗原
生物物理学
免疫学
生物
作者
Zhihui Liang,Xin Wang,Guang Yu,Min Li,Shuting Shi,Hang Bao,Chen Chen,Duo Fu,Wei Ma,Changying Xue,Bingbing Sun
出处
期刊:Nano Today
[Elsevier]
日期:2022-04-01
卷期号:43: 101445-101445
被引量:18
标识
DOI:10.1016/j.nantod.2022.101445
摘要
Aluminum oxyhydroxide (AlOOH) adjuvants are widely used in human vaccines. However, the interaction mechanisms at the material-bio interface, and further understandings on physicochemical property-dependent modulation of the immune responses still remain uncertain. Herein, a library of AlOOH nanorods with well-defined aspect ratios is designed to explore the mechanisms of adjuvanticity. The aspect ratios of AlOOH nanorods were demonstrated to be intrinsically modulated by the hydroxide supersaturation level during crystal growth, leading to the differences in surface free energy (SFE). As a result, higher aspect ratio AlOOH nanoadjuvants with lower SFE exhibited more hydrophobic surface, resulting in more membrane depolarization, cellular uptake and dendritic cell (DC) activation. By using hepatitis B surface antigen (HBsAg) virus-like particles (VLPs) or SARS-CoV-2 spike protein receptor-binding domain (RBD) as model antigens, AlOOH nanorods with higher aspect ratio were determined to elicit more potent humoral immune responses, which could be attributed to the enhanced DC activation and the efficient antigen trafficking to the draining lymph nodes. Our findings highlight the critical role of aspect ratio of AlOOH nanorods in modulating adjuvanticity, and further provide a design strategy for engineered nanoadjuvants for prophylactic vaccines.
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