细胞生物学
间充质干细胞
微图形化
旁分泌信号
免疫系统
再生(生物学)
脚手架
化学
生物
免疫学
材料科学
生物医学工程
医学
纳米技术
生物化学
受体
作者
Bingjun Zhang,Fei Han,Yufeng Wang,Yu-Hua Sun,Rui Zhang,Xiaopeng Yu,Chen Qin,Hongjian Zhang,Chengtie Wu
标识
DOI:10.1002/advs.202200670
摘要
Natural tissues are composed of ordered architectural organizations of multiple tissue cells. The spatial distribution of cells is crucial for directing cellular behavior and maintaining tissue homeostasis and function. Herein, an artificial bone bioceramic scaffold with star-, Tai Chi-, or interlacing-shaped multicellular patterns is constructed. The “cross-talk” between mesenchymal stem cells (MSCs) and macrophages can be effectively manipulated by altering the spatial distribution of two kinds of cells in the scaffolds, thus achieving controllable modulation of the scaffold-mediated osteo-immune responses. Compared with other multicellular patterns, the Tai Chi pattern with a 2:1 ratio of MSCs to macrophages is more effective in activating anti-inflammatory M2 macrophages, improving MSCs osteogenic differentiation, and accelerating new bone formation in vivo. In brief, the Tai Chi pattern generates a more favorable osteo-immune environment for bone regeneration, exhibiting enhanced immunomodulation and osteogenesis, which may be associated with the activation of BMP-Smad, Oncostatin M (OSM), and Wnt/β-catenin signaling pathways in MSCs mediated by macrophage-derived paracrine signaling mediators. The study suggests that the manipulation of cell distribution to improve tissue formation is a feasible approach that can offer new insights for the design of tissue-engineered bone substitutes with multicellular interactions.
科研通智能强力驱动
Strongly Powered by AbleSci AI