三氟乙酸酐
化学
Pummer重排
烷基
试剂
羧酸盐
盐(化学)
有机化学
组合化学
醋酸酐
催化作用
作者
Peng Qi,Fanghong Sun,Ning Chen,Hongguang Du
标识
DOI:10.1021/acs.joc.1c02502
摘要
A base-free bis-alkyl thiolation reaction of indoles with sulfinothioates under Pummerer-type conditions is described. Sulfinothioates, activated with 2,2,2-trifluoroacetic anhydride, are demonstrated to be an efficient thiolation reagent for wide applications. This approach enabled double C-H thiolation at the C2 and C3 of the indole in one pot. The mechanism studies suggested the thiolation was realized through the sulfoxonium salt rather than sulfenyl carboxylate.
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