纳米医学
药物输送
纳米技术
生物界面
日冕(行星地质学)
靶向给药
纳米颗粒
材料科学
化学
生物
天体生物学
维纳斯
作者
Donghui Song,Qiaobing Xu
出处
期刊:Langmuir
[American Chemical Society]
日期:2022-07-19
卷期号:38 (30): 9092-9098
被引量:5
标识
DOI:10.1021/acs.langmuir.2c01609
摘要
The field of nanomedicine has rapidly grown in the past decades. Although a few nanomedicines are available in the market for clinical use, it is still challenging to develop nanomedicine targeting tissues beyond the liver. It has been recognized that even though the nanoparticles are modified with targeting ligands, the formation of a protein corona on the surface of nanoparticles in the biological fluids results in limited progress in nanoparticle-based drug delivery to specific cells or tissues. In this Perspective, we will discuss the role of surface properties in determining the formation of the protein corona and summarize the recent progress in engineering the nano/bio interface for protein-corona-mediated cell- and organ-selective drug delivery. Moreover, current challenges in the field and insights into designing new strategies for targeting drug delivery with a better understanding of the protein corona will be discussed.
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