[EC‐01–04]: The Role of PICALM and LRP1 in Transvacular Abeta Clearance Across the Blood Brain Barrier

Zhen Zhao will address the pathways of clearance of Ab across the walls of blood vessels. Transvascular clearance of Amyloid β (Aβ) across the blood-brain barrier (BBB) is a major pathway for flushing Aβ out from brain to circulation. The endothelial Aβ receptors, such as LRP1, capture brain Aβ species, while the transcytosis machinery, including PICALM, effectively drive the cargos through endocytosis, intracellular trafficking and exocytosis. Impaired vascular Aβ clearance results in elevated brain Aβ level and exacerbates AD pathologies. Piling evidence has demonstrated that the alteration of this transvascular clearance system, particularly abnormal expression of AD vascular risk genes such as PICALM and LRP1 in cerebral vasculature, contributes to AD pathogenesis.