人参皂甙
代谢工程
生物合成
酵母
生物技术
酶
生物化学
生物
计算生物学
化学
传统医学
人参
医学
病理
替代医学
作者
Jin-Ling Yang,Zong-Feng Hu,Tingting Zhang,An-Di Gu,Ting Gong,Ping Zhu
出处
期刊:Molecules
[MDPI AG]
日期:2018-03-06
卷期号:23 (3): 589-589
被引量:40
标识
DOI:10.3390/molecules23030589
摘要
As the main bioactive constituents of Panax species, ginsenosides possess a wide range of notable medicinal effects such as anti-cancer, anti-oxidative, antiaging, anti-inflammatory, anti-apoptotic and neuroprotective activities. However, the increasing medical demand for ginsenosides cannot be met due to the limited resource of Panax species and the low contents of ginsenosides. In recent years, biotechnological approaches have been utilized to increase the production of ginsenosides by regulating the key enzymes of ginsenoside biosynthesis, while synthetic biology strategies have been adopted to produce ginsenosides by introducing these genes into yeast. This review summarizes the latest research progress on cloning and functional characterization of key genes dedicated to the production of ginsenosides, which not only lays the foundation for their application in plant engineering, but also provides the building blocks for the production of ginsenosides by synthetic biology.
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